Reversal of oral anticoagulant induced bleeding

I tried to create a heuristic approach to reversal of oral anticoagulant induced bleeding.

Four basic principles guide your approach:

  1. Identify the drug and it’s mechanism of action as either anti-platelet or anti-clotting cascade.
  2. Predict the time to hemostasis (or loss of anticoagulation effect) with  no intervention (mechanism of action, metabolism, elimination, hepatic function, renal function, etc)
  3. Establish the time frame for the NEED for hemostasis
  4. Decide to intervene or not and pick an intervention typically combining a) antidotes, b) factor replacement, c) platelet transfusion, or d) procoagulants… depending.

Here it is:

Reversing Anticoagulant Induced Bleeding



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